Abstract
The effect of pH on the neurogenic contractile response to electrical field stimulation (at frequencies of 1, 3, 10, and 40 Hz) of the rat internal carotid artery segment in the absence and in the presence of 0.01-10.0 μM noradrenaline was studied. In the absence of noradrenaline, acidosis (рН 6.6) was shown to inhibit this response most significantly at high frequencies of stimulation, while in the presence of noradrenaline, acidosis rather potentiated and alkalosis (рН 7.6) inhibited the response most significantly at low frequencies of stimulation used. Acidosis tended to increase the artery contraction evoked by noradrenaline in all concentrations except for 10.0 μM. Noradrenaline potentiated the neurogenic vasoconstriction, which was more pronounced at noradrenaline concentrations from 0.5 μM to 10.0 μM, increased at acidosis and decreased at alkalosis. Increase in the contractility of the internal carotid artery under the condition of the pH shift from alkaline to acidic may be of importance for the prevention of the increase in the cerebral perfusion pressure during exercise characterized by elevated blood pressure, acidosis, and increased levels of noradrenaline.
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