Морфо-функциональные проявления острого респираторного дистресс-синдрома и его коррекция СВЧ-излучением в эксперименте

Abstract

Microwave irradiation of animals on the frequency of the resonance transparency of aqueous media at the power flux density 10 NW/cm2 didn’t accompanied by a statistically significant effect on the severity of experimental acute respiratory distress syndrome. Analysis of the distribution of pulmonary index, as an indicator of the severity of the alveolar-capillary disorders, suggests that while the power flux density of microwave radiation 10NW/cm2, its normalization occurs in 40% of the animals. It is noted that in this capacity, there is a reduction in the proportion of animals with lung index in the range of 8-12% from 60 to 20% (p=0.011). The statistical analysis revealed significant differences distributions it absolute values in this group and the comparison group, in which microwave irradiation hasn’t been conducted (χ2=36,4; р=0,001). Microwave irradiation with the power flux density 50 NW/cm2 is manifested by normalization of pulmonary index in 83% of the animals. However, in 17% of animals subjected to such exposure it was noted the high conservation values of the index, which doesn’t exceed 12 units. The increase of power of microwave radiation of up to 80 NW/cm2 is accompanied by normalization of the manifestations of acute distress syndrome in 77% of the animals (p<0.001). The analysis showed that the effect of microwave radiation on the cell culture of whole blood in low power flux density is accompanied by growth in supernatant the concentration bradikinin by 5.6% (p=0.37), NO by 0.54% (p=0,81) and Pg I2 by 0.35% (p=0,87). It is noted that with the increase of density of up to 50 NW/cm2, further increasing the concentration bradikinin by 34.6% (p=0.033), NO by 1.43% (p=0.21), Pg I2 by 0.91% (p=0,76) in comparison with control occurs. A further increase to 80 NW/cm2 contributed to the growth of the concentration bradikinin by 38.3% (p=0.01), NO by 2,33% (p=0,17) and Pg I2 – by 1,4% (р=0,17).