Abstract
The effect of the selective PDE-4 inhibitor rolipram, which eliminates cAMP degradation, on osmoregulatory function in WAG and Brattleboro rats with different blood vasopressin (AVP) level was studied. It was found that in WAG rats with high endogenous AVP level treatment of rilipram induced the significant acceleration of the urine flow rate as a result of the increase in sodium excretion and also the decrease in solute‐free water reabsorption. The changes in the functional parameters were followed by an increase in the content of glycosaminoglycans, which determine the permeability of the interstitial matrix in the AVP-sensitive renal medulla. At the same time in AVP-deficient Brattleboro rats with low adenylate cyclase system activity in the kidney rolipram treatment induced the development of the antidiuretic response whithout changes in the parameters of natriuretic function and the state of the interstitial renal matrix. These results showed a significant influence of rolipram, which eliminates the degradation of cAMP by the inhibition of PDE4, on the osmoregulatory renal function, changes parameters of which are mainly determined by the AVP level and the integration of effects mediated by V2- and V1a-like vasopressin receptors.
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