Генетические маркеры сердечно-сосудистых факторов риска и артериальной гипертензии в коренной популяции Горной Шории

Abstract

Objective. To study the prevalence of the genetic risk factors and their role in the formation of hypertension and its risk factors among indigenous population of Mountain Shoria (Shors). Design and methods. A clinicalepidemiological study of Mountain Shoria indigenous populations at isolated regions was undertaken. We examined 395 people by continuous method, the sample included adult population (aged 18 years and older). We studied anthropometric data, blood lipids, and polymorphisms of the genes ADRB1 (Ser49Gly, A/G, rs1801252) ADRA2B (I/D), ACE (I/D), eNOS (4a/4b) and MTHFR (C677T, Ala222Val, rs1801133). Results. Mean levels of triglycerides, total cholesterol, very low density lipoproteins and atherogenic index were higher among people with homozygous DD genotype ADRA2B gene. D allele of the ADRA2B gene was found 2,8‑times more frequently among Shors with obesity in comparison to the population with normal weight. There is a 7,9‑time higher relative risk to detect D allele of the ACE gene among people with hypercholesterolemia than among people with normal levels of total cholesterol, and it is 11,2 times higher in group with hyperbetacholesterolemia than in group with normal levels of low density lipoprotein cholesterol. A allele homozygotes of the ADRB1 gene have 1,6 times higher risk of hypertension development in comparison with G allele homozygotes and heterozygotes. Conclusions. Ther is a relation between Ser49Gly polymorphism of ADRB1 gene with atherogenicity index, I/D polymorphism ADRA2B gene with triglyceride level, low density lipoprotein cholesterol, atherogenic index, I/D polymorphism of ACE gene and the levels of total cholesterol and low density lipoprotein cholesterol. D allele of ADRA2B gene is associated with obesity, and abnormal fat distribution. An allele of ADRB1 gene is associated with the higher relative risk of hypertension progression in Shor population.