Abstract
Objective : to identify markers of tissue hypoxia in ulcerative colitis and methods for overcoming it. Materials and methods : 77 children with ulcerative colitis (UC) aged 1 year to 18 years were examined. Retrospectively analyzed biopsy samples in patients with verifi ed course of ulcerative colitis, including those operated on, during initial hospitalization. Histological, histomorphometric and immunohistochemical analysis of biopsy samples of the mucous membrane of the colon and ileum was performed. Results: morphological markers of tissue hypoxia in UC were revealed: increased fi broplastic activity, small focal lipomases, small intestinal metaplasia in the distal colon, determined by the presence of Paneth cells, changes in the distal ileum in the colon type. Conclusion : when identifying markers of tissue hypoxia, leading to a worsening prognosis of UC and the ineff ectiveness of therapeutic treatment, it is necessary to use accelerated “step-up” therapy, including the early administration of anticytokine drugs and use the hyperbaric oxygenation method.
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