Роль полиморфных локусов генов аргинин-вазопрессиновых рецепторов в саморегуляции поведения у психически здоровых индивидов

Abstract

Self-regulation is the ability to control one’s behavior, emotions, and thoughts in the pursuit of long-term goals. It’s assumed that individual differences in a system of self-regulation arise from complex interactions between environmental and hereditary factors, that may be linked to abnormal functioning of neurotransmitter systems in the brain yet the underlying genetic mechanisms remain unclear. The present study aimed to assess the main effects of arginine-vasopressin receptor gene polymorphisms (AVPR1A (rs1042615 and rs3803107), AVPR1B (rs28632197 and rs33911258)) and gene-environmental interactions on individual differences in a system of self-regulation of behavior in 692 mentally healthy individuals with sex and ethnicity inclusion as covariates. Statistical analysis revealed the association of AVPR1A rs1042615 A-allele with an increased score on the modeling scale in women (β = 0,212; r2 = 0,008; P = 0,039) and Udmurts (β = 0,41; r2 = 0,032; P = 0,044), as well as the association of AVPR1B rs28632197 A-allele with an increased score on the programming scale in Tatars (β = 0,212; r2 = 0,008; P = 0,039). In addition, we revealed that «maltreatment», «smoking», «residence (rural)», «family content (incomplete family)», «order of birth (third child and younger)» and significantly affected on association of rs1042615, rs3803107, rs28632197 и rs33911258 and individual differences in a system of self-regulation of behavior (P < 0,03).