Abstract
Introduction. The effectiveness of TB vaccination is low in more than half of children with tuberculosis, which is confirmed by the small size of the post-vaccination scar or its absence. Having a residual virulence, the BCG strain can cause the development of post-vaccination complications. Objective – to conduct a comparative analysis of the frequency and structure of complications of TB vaccination with BCG and BCG-M in children. Material and methods. The analysis of the frequency and structure of complications was carried out in 284 children in BCG vaccination, in 273 children in BCG-M vaccine. Results. The use of BCG-M vaccine reduced the frequency and proportion of complications, and improved the structure of post-vaccination complications. The development of complications is associated with altered immunological reactivity of the child, which is manifested by a decrease in the activation potential of T-lymphocytes and functional insufficiency of humoral immune cells. Conclusions. During the period of TB vaccination, a thorough clinical and laboratory analysis of children with perinatal pathology is necessary to exclude immune insufficiency and reduce the risk of complications.
Highlights
The effectiveness of TB vaccination is low in more than half of children with tuberculosis, which is confirmed by the small size of the post-vaccination scar or its absence
Проведен сравнительный анализ частоты и структуры осложнений на противотуберкулёзную вакцинацию с использованием вакцины БЦЖ у 284 детей за 10-летний период 20002009 гг. и у 273 детей, вакцинированных вакциной БЦЖ-М, за период 2010-2019 гг
При этом БЦЖ-лимфадениты до 94% выявлялись в активной стадии развития и только 6% – в стадии обызвествления, что достоверно меньше, чем в период использования вакцины
Summary
The effectiveness of TB vaccination is low in more than half of children with tuberculosis, which is confirmed by the small size of the post-vaccination scar or its absence. Провести сравнительный анализ частоты и структуры осложнений на противотуберкулёзную вакцинацию вакциной БЦЖ и БЦЖ-М у детей. Анализ частоты и структуры осложнений проводился у 284 детей на вакцинацию вакциной БЦЖ, у 273 детей на вакцину БЦЖ-М. С. Сравнительный анализ частоты и структуры осложнений на противотуберкулезную вакцинацию вакциной БЦЖ и БЦЖ-М / А.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
