Abstract
Nowadays the cerebral vascular diseases are recognized as the main causes of disability and mortality, and the issues of optimizing the pathogenetic therapy of this disease remain far from being solved. In this regard, the development of new effective methods to combat the development and progression of cerebrovascular disorders in dyscirculatory encephalopathy (DE) is the most important task of medicine and biology. In this paper, we evaluated the morphological and morphometric parameters of brain tissue in the SHR rats 30 days after applying the rhythmic craniocerebral hypothermia and cryopreserved cord blood nucleated cells. It has been shown that each of the studied methods of influence has a more or less positive effect on reducing the severity of degeneration in the tissue of rat’s brain with the DE signs. The combined use of these methods contributed to their mutual potentiation, manifested in a decrease in the degree of degenerative-dystrophic lesions of brain tissue, as evidenced by a significant decrease in the neuroglial index. Probl Cryobiol Cryomed 2019; 29(1): 058–072
Highlights
Nowadays the cerebral vascular diseases are recognized as the main causes of disability and mortality, and the issues of optimizing the pathogenetic therapy of this disease remain far from being solved
The cryopreserved cord blood cell suspension was a suspension of nucleated cells isolated by sedimentation in a dextran density gradient with the molecular weight of 60,000 (Yuria Pharm, Ukraine) and frozen in autoplasma with dimethyl sulfoxide (DMSO) cryoprotectant at a final concentration of 5% according to the original method [6, 7]
As we demonstrated earlier, spontaneously hypertensive spontaneously hypertensive rats (SHR) rats can serve as an adequate model of dyscirculatory encephalopathy (DE)
Summary
Nowadays the cerebral vascular diseases are recognized as the main causes of disability and mortality, and the issues of optimizing the pathogenetic therapy of this disease remain far from being solved. The combined use of these methods contributed to their mutual potentiation, manifested in a decrease in the degree of degenerative-dystrophic lesions of brain tissue, as evidenced by a significant decrease in the neuroglial index. В этой связи крысы линии SHR, спонтанно развивающие АГ, могут быть перспективными моделями для изучения цереброваскулярных заболеваний [19, 22] и сосудистой деменции [18, 23]. К наиболее перспективным СК можно отнести клетки кордовой крови (КК) человека [21]
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
