Abstract
The possibility of using spontaneously hypertensive rats (SHR) as an adequate of dyscirculatory encephalopathy model was investigated. Morphological, morphometric parameters and intensity of processes of lipid peroxidation (malonic dialdehyde (MDA) content) in the brain tissue of white outbred rats (assumed as a normotensive control) and SHR rats were assessed, as well as their blood pressure, blood viscosity and hematocrit were analyzed. In the SHR rats, the changes in architectonics of the brain vascular bed and degenerative-dystrophic lesions of the brain tissue were noted on the background of significantly high blood pressure, increased blood viscosity, reduced oxygen delivery to tissues, and high MDA content (compared with normotensive control). It has been established that SHR rats can be used for developing the ways of correction of pathologically changed brain structures using the methods of craniocerebral hypothermia as well as introduction of cryopreserved cells of cord blood. Probl Cryobiol Cryomed 2018; 28(3): 224 – 236
Highlights
The possibility of using spontaneously hypertensive rats (SHR) as an adequate of dyscirculatory encephalopathy model was investigated
Monitoring of blood pressure in outbred white rats has confirmed the stability of the recorded indices at BP of 127 mm Hg, which corresponds to the averaged reported data for normotensive animals [6] (Table 1)
The rise in the hematocrit level in SHR rats can be associated with an increased amount of blood erythrocytes, which is a compensatory reaction of the body to developing hypoxia and is characterized with an enhanced bone marrow production of red blood cells
Summary
The possibility of using spontaneously hypertensive rats (SHR) as an adequate of dyscirculatory encephalopathy model was investigated. It has been established that SHR rats can be used for developing the ways of correction of pathologically changed brain structures using the methods of craniocerebral hypothermia as well as introduction of cryopreserved cells of cord blood. Дисциркуляторная энцефалопатия (ДЭ) – хроническая прогрессирующая форма цереброваскулярной патологии, характеризующаяся ишемическим (многоочаговым или диффузным) поражением головного мозга (ГМ) с постепенным развитием комплекса неврологических и нейропсихологических расстройств, приводящих к развитию когнитивных нарушений (сосудистая деменция). В этой связи крысы линии SHR являются перспективной моделью для изучения неврологическо-поведенческих расстройств
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