Маркери оксидативного стресу у вагітних із затримкою росту плода та їхній вплив на результати розродження

Abstract

The objective: estimate the oxidative stress markers and their influence on result of labour process of pregnant women with fetus growth inhibition. Materials and methods. The complex examination of 63 pregnant women was made in term of 28–34 weeks of gestation and in dynamics (examination in 3–4 weeks). І group includes 33 pregnant women with fetus growth inhibition. Group ІІ was presented by 30 pregnant women without fetus growth inhibition. Markers of oxidative modification of proteins were analyzed in blood serum by means of spectrophotometric method and glutathione level was analyzed by fluorometric method. Variational and statistical processing of results was made using Statistica 13 – license standard application program packages for multidimensional statistical analysis. Results. Estimation results of markers of oxidative modification of proteins and glutathione level in pregnant women of group under investigation in dynamics indicate the progress of imbalance between oxidants and antioxidants among pregnant women with fetus growth inhibition compared to women without fetus growth inhibition (p<0.05). Such changes occur in conditions of lack of glutathione which level was significantly and statistically lower (p<0.05) in pregnant women with fetus growth inhibition. These results indicate intensification of oxidative modification of proteins together with decrease of reserve and adaptive abilities of antioxidant system of serum in the present group of pregnant women and it is the manifestation of oxidative stress. Pregnancy course and labour in case of women with fetus growth inhibition is characterized by rise of complication percentage that has negative effect both on rate of operative labour process and perinatal complications. Conclusions. Pregnancy course complicated by fetus growth inhibition is characterized by intensification of oxidative modification of proteins with decrease of reserve and adaptive abilities of antioxidant system of serum. These results indicate occurrence of oxidative stress in this group of women. It should be considered as one of the important links of pathogenesis of fetus growth inhibition. Course of labour among women with fetus growth inhibition is characterized by increase of complication rate that has direct influence on percentage rise of operative labour process under urgent indications. Condition of infants with growth inhibition at birth is characterized by significant and statistical decrease of average indicators under Apgar score and in case of estimation of anthropometric indicators it is characterized by significant and statistical (р < 0.05) decrease of weight-height parameters of newborns. Key words: pregnancy, fetus growth inhibition, oxidative modification of proteins, antioxidative system of protection, obstetric and perinatal complications