Дисбаланс некоторых цитокинов и матриксных металлопротеиназ как маркеров местного воспаления в патогенезе первичной открытоугольной глаукомы

Abstract

Purpose. To study the content of cytokines and matrix metalloproteinases in the intraocular fluid in patients with advanced stage of primary open-angle glaucoma. Material and methods. 50 patients were examined with a verified diagnosis of the advanced stage of POAG. The control group consisted of 30 patients with a diagnosis of uncomplicated cataract. The concentration of the determined biologically active molecules was carried out by the method of flow fluorimetry on a two-beam laser analyzer Bio-Plex 200, Bio-Rad, USA. Results. A statistically significant increase in the concentrations of IL-6, 8, 17, TGF-1, 2, 3, matrix metalloproteinase-2 and tissue inhibitors of matrix metalloproteinases-1, 2, 3, 4 was found in the intraocular fluid of patients with POAG. Conclusion. The data obtained indicate the significance of the local inflammatory process, as well as disturbances in the structure of the extracellular matrix and its remodeling in the mechanisms of POAG development. Keywords: primary open-angle glaucoma, intraocular fluid, cytokines, matrix metalloproteinases, tissue inhibitors of matrix metalloproteinases.