Уровень оксидативного стресса и нарушения антиоксидантной способности крови у детей и подростков с метаболическим синдромом

Abstract

The purpose of the study is to assess the level of oxidative stress and impaired blood antioxidant capacity in children and adolescents with metabolic active obesity and other components of the metabolic syndrome. Materials and methods. Surveyed 102 children and adolescents aged 10 to 15 years with obesity. According to the results of clinical and laboratory examinations, groups were identified depending on the presence of metabolic disorders: metabolic active obesity (MAO) and metabolically healthy obesity (MHO). The comparison group consisted of 230 schoolchildren of secondary educational institutions of the city of Arkhangelsk. Results. When comparing groups with MAO, MHO and children without metabolic disorders, it was found that the highest average level of total peroxide (PPS) is observed in the group with MAO, the lowest in the comparison group (<0.001). Among the average indicators of the general antioxidant system (GAS), on the contrary, the lowest value is observed in the group with MAO, the highest - in the comparison group, in children and adolescents with MLO - intermediate values of AOS. The average levels of the studied parameters of proatherogenic metabolic disorders (uric acid (UA), lipid spectrum, glucose, C - reactive protein, blood pressure, HOMA index, insulin) were significantly higher in the group with MAO, except for the average level of high density lipoprotein cholesterol (HDL cholesterol), which is significantly lower. Conclusion. In children and adolescents with MAO, changes in the classic indicators of atherogenic disorders (blood lipid spectrum, blood pressure, insulin resistance, hyperinsulinemia, chronic inflammation) and high levels of oxidative stress are found, along with a decrease in the activity of the antioxidant system, which may have not only pathogenetic significance, but also reveals promising areas for the prevention and treatment of atherogenic disorders.