Abstract
Objective: To investigate the level of leptin in patients with gastroesophageal reflux disease with concomitant obesity and evaluate its effect on the course of the disease. Materials and results. The study involved 50 patients. The first group included patients with GERD with concomitant obesity, the second group — patients with GERD without concomitant pathology. A survey was conducted using the GERDQ questionnaire, which showed that patients with concomitant obesity were more likely to have symptoms of the disease. Leptin levels were determined by enzyme-linked immunosorbent assay. Іn subjects of group 1, the concentration of leptin will be significantly higher than in patients of group 2. An endoscopic study was performed, the results of which were compared with the concentration of leptin. There is a direct correlation between body mass index, the degree of esophageal damage and leptin levels.
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