Abstract

 
 
 The article presents the results of a study on the effectiveness of a substance based on silk fibroin, obtained at the Institute of Chemistry and Polymer Physics of the Academy of Sciences of the Republic of Uzbekistan, in eliminating disorders of lipid metabolism in the body. In experiments in rats with experimental hypercholesterolemia, the substance was found to have a cholesterol-lowering property, which is manifested by a decrease in cholesterol level both in blood and in tissues. Studies on the mechanism of the hypocholesterolemic effect of the studied substance have shown its effects on the enterohepatic pathway of bile acids, which makes it possible to classify this substance as a group of bile acid sequestrants.
 
 
Highlights
The article presents the results of a study on the effectiveness of a substance based on silk fibroin
which is manifested by a decrease in cholesterol level
Studies on the mechanism of the hypocholesterolemic effect of the studied substance have shown its effects on the enterohepatic pathway of bile acids
Summary
Желчь для исследования собирали в течение 4 часов под этаминаловым наркозом (50 мг/кг внутрибрюшинно) канюлированием общего желчного протока; измеряли её объем и определяли содержание желчных кислот, холестерина и билирубина по вышеуказанным методам. При лечении животных с веществом БС-1 содержание общих липидов и холестерина статистически значимо снизилось на 28,3 и 28,8% соответственно по сравнению с контрольными значениями, оставаясь при этом выше интактных значений на 163,5 и 46,3% соответственно. Результаты исследования показали, что ГХС сопровождается повышением в ткани печени содержания общих липидов и холестерина на 167,5 и 405% по сравнению с интактными значениями
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