Особенности системных и местных иммунных реакций у кольских саамов и русских, проживающих на Крайнем Севере.

Abstract

The features of systemic and local immune reactions in the Kola Sami and Russians living in the Far North were studied. A decrease in the total number of leukocyte cells in the Sami was established, associated with frequent registration of leukopenia, lymphopenia, and neutropenia. A deficiency in the phagocytic activity of neutrophils in the blood and secretions of the mucous membranes and an increase in the content of lymphocytes with CD4+ and CD8+ receptors were revealed. In Russian residents, leukocytosis, lymphocytosis, neutrophilia, monocytosis and eosinophilia were more often recorded with an increase in the content of natural killer cells, IL-6 and IL-10. The Sami and Russians are characterized by high levels of IgE, which have more pronounced cytotoxicity and indicate strain on the immune mechanisms. The Sami have higher levels of leukocyte migration into mucosal-associated tissue of the mucous membranes, which is associated with a decrease in the sorption capacity of epithelial cells, the phagocytic activity of neutrophils and the concentrations of secretory immunoglobulins.