Abstract
The features of systemic and local immune reactions in the Kola Sami and Russians living in the Far North were studied. A decrease in the total number of leukocyte cells in the Sami was established, associated with frequent registration of leukopenia, lymphopenia, and neutropenia. A deficiency in the phagocytic activity of neutrophils in the blood and secretions of the mucous membranes and an increase in the content of lymphocytes with CD4+ and CD8+ receptors were revealed. In Russian residents, leukocytosis, lymphocytosis, neutrophilia, monocytosis and eosinophilia were more often recorded with an increase in the content of natural killer cells, IL-6 and IL-10. The Sami and Russians are characterized by high levels of IgE, which have more pronounced cytotoxicity and indicate strain on the immune mechanisms. The Sami have higher levels of leukocyte migration into mucosal-associated tissue of the mucous membranes, which is associated with a decrease in the sorption capacity of epithelial cells, the phagocytic activity of neutrophils and the concentrations of secretory immunoglobulins.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Transactions of the Kоla Science Centre. Series: Natural Sciences and Humanities
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
