Abstract
The effect of endocannabinoids on corticosterone secretion and norepinephrine release in the amygdala during the acute stress of elevated platform was studied using the brain microdialysis with a means of CB1 receptors antagonist rimonabant and anandamide uptake inhibitor AM-404 in C57Bl/6N mice. Rimonabant (3 mg kg, p.o.) stimulated the stress-evoked secretion of corticosterone that reaffirms the CB1 receptors tuning the HPA axis activity and suggests that they rather control the amplitude of corticosterone secretion, than its duration. Stress was accompanied by a transient increase in the release of norepinephrine in the amygdala. AM-404 (3 mg/kg, i.p.) suppressed but did not completely inhibit the elevated platform stress-induced release of norepinephrine and put it back to control levels. The results designate anandamide as a regulator of presynaptic release of norepinephrine in the amygdala during the psychological stress.
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