Abstract
Serum FDP was found to be elevated in patients with liver cirrhosis, but we are still unable to clearly differentiate between primary fibrinolysis and fibrinolysis secondary to disseminated intravascular coagulation (DIC)Whether elevated FDP shows secondary fibrinolysis or not was investigated in 31 patients with decompensated liver cirrhosis.The following tests were performed: hepaplastin test, prothrombin time, anti-thrombin III, plasminogen activator, fibrinogen, plasminogen, α2 plasmin inhibitor and FDP.The following results were obtained.1) Decompensated liver cirrhosis is associated with hypercoagulable and hyper-fibrinolytic states.2) The patients with 20μg/ml or less of FDP (25 of 31 cases (84%) of decompensated liver cirrhosis), were not in hypercoagulable state but were in hyper-fibrinolytic state . Therefore, we thought that these cases do not have a tendency of developing DIC.3) On the other hand, in the patients with 40μg/ml or more of FDP (5 of 31 cases (16%) of decompensated liver cirrhosis), hypercoagulable and hypofibrinolytic states were in front. Therefore, these cases have secondary fibrinolysis.
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