Abstract
The present study is devoted to revealing the peculiarities of the reaction of tissue microhemodynamics and cardiorespiratory system of animals the action acetylsalicylic acid in different concentrations on in rats. The study was carried out on the basis of the Center for collective use of scientific equipment «Experimental Physiology and Biophysics» of the Department of Human and Animal Physiology and Biophysics of the V. I. Vernadsky Crimean Federal University. The animals were divided into six groups of 10 animals. The first group was biological control; in the animals of this group, the microcirculation parameters were recorded by the laser Doppler flowmetry (LDF) method. The second-sixth group of animals was registered parameters of microcirculation and cardiorespiratory system. The LDF-metry was performed with the help of the laser analyzer of the blood flow «LAZMA-MC». It was researched the action of 5, 10, 40, 80, and 120 mg/kg doses acetylsalicylic acid on cardiorespiratory parameters in rats. It was found that the effect of acetylsalicylic acid in all doses significantly decreased only heart rate. The maximum decrease in this indicator was registered in animals when acetylsalicylic acid was administered at a dose of 120 mg/kg by 24.4 % (p≤0.05) relative to the values in the control group of animals. When acetylsalicylic acid was administered in isolated doses, there was a significant change in the activity of almost all components of microvascular tone regulation. These changes were most pronounced when animals were administered acetylsalicylic acid at a dose of 80 mg/kg. Thus, the action of acetylsalicylic acid it was increased the endothelium-dependent vasodilation, blood flow to the nutritive microvasculars, improvement in venular outflow and decreased in peripheral resistance. The reported study was funded by RFBR, project number 20-33-70142.
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