Abstract
Background. Cases of combined consumption of surfactants (alcohol and opiates) in both the adult population and adolescents are quite common at present. An important role in the functional activity of the central nervous system is played by neuroactive amino acids, the level of which changes under the influence of psychotropic substances.Purpose. To study the content of neuroactive amino acids in the cerebral cortex, striatum, hypothalamus, midbrain and cerebellum in acute alcohol and morphine intoxication, as well as the complex administration of these substances.Material and methods. The experiments were carried out on white outbred male rats. Using the HPLC method in different parts of the brain, the levels of neurogenic amino acids were determined in acute alcohol and morphine intoxication, as well as their complex administration in different sections.Results. Acute complex morphine-alcohol intoxication is accompanied by manifestation of excitation processes in the striatum and hypothalamus, as well as inhibition in the midbrain. Alcohol-morphine intoxication leads to an increase in the content of GABA in all brain regions studied except the hypothalamus.Conclusion. Morphine-alcohol intoxication is accompanied by a decrease in the glycine content in the striatum, as well as an increase in its concentration in the midbrain and the level of glutamate in the hypothalamus. Alcohol-morphine intoxication leads to an increase in GABA levels in the cerebral cortex, striatum, midbrain and cerebellum.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
