Abstract
The designing of novel approaches and search for more efficient means to normalize the thyroid gland (TG) function in autoimmune thyroiditis (AIT) is a topical task in current endocrinology. Here we assessed the effect of cryopreserved allogeneic fetal liver cells (cFLCs) and those of fetal mesodermal tissues (cFMTCs) on thyroid gland (TG) morphostructure in rats with experimental AIT. The cFLCs and cFMTCs were demonstrated to positively affect the TG of rats with induced AIT even at the early stages of the study. Both types of fetal cells potentiated the thyrocyte proliferation and microfollicle differentiation even in 7 days after administration. This effect persisted during a month of observation. Herewith the cells of mesodermal origin had a more pronounced effect than the fetal liver ones. Our findings testify to the prospects of using stem and progenitor cells of fetal origin for AIT correction, that may be the basis in designing a novel efficient approach to the therapy of autoimmune damage of thyroid parenchyma.Probl Cryobiol Cryomed 2017; 27(4): 356-366
Highlights
The development of novel approaches and search for more efficient means to normalize the thyroid gland (TG) function in autoimmune thyroiditis (AIT) is an urgent task in current endocrinology
This research was aimed to study the effect of cryopreserved allogeneic fetal liver cells and fetal mesodermal cells on morphological structure of TG in rats with experimental autoimmune thyroiditis
In 1.5 months after completing immunization, in all the animals with experimental AIT a pronounced rearrangement of TG parenchyma and stroma was preserved: the follicles lost their shape, disintegrated and formed the fields of epithelial cells, with no colloid observed in these areas, the connective tissue layers were significantly expanded and elongated in many sites (Fig. 3)
Summary
The development of novel approaches and search for more efficient means to normalize the thyroid gland (TG) function in autoimmune thyroiditis (AIT) is an urgent task in current endocrinology. The cFLCs and cFMTCs positively affected the TG of rats with induced AIT even at the early stages of the study Both types of fetal cells potentiated the thyrocyte proliferation and microfollicle differentiation already in 7 days after administration. Основою патогенезу цього захворювання є аутоімунний процес, який призводить до часткової або повної деструкції тиреоїдної паренхіми з розвитком характерних морфологічних змін та секреторної недостатності ЩЗ. Єдиною специфічною ознакою АІТ вважається певний характер морфологічних змін у залозі: атрофія паренхіматозних клітин, фіброз, збільшення кількості оксифільних клітин (клітин Гюртле) та дифузна лімфоїдна інфільтрація тиреоїдної паренхіми, яка виникає за рахунок аутоімунних факторів [23, 36]. Хірургічний спосіб лікування АІТ, який полягає у резекції усієї або деякої частини ЩЗ, часто є неефективним, навіть небезпечним, через загрозу розвитку найближчих та віддалених ускладнень. Наявність гіпотиреозу з аутоімунним компонентом потребує призначення замісної терапії препаратами тирок-
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