Abstract
We are generally believed that optimal muscular function and hypertrophy gains are induced via moderate- or high-intensity resistance training, equivalent to at least 70% of an individual’s 1 repetition maximum. In recent years, systemic hypoxic stress has emerged as a stimulation condition that can induce more physiological and biochemical changes caused by resistance exercise. Hypoxic stress result in changes in neuromotor control, metabolic changes, hormonal changes, cellular swelling, and intracellular signaling pathways, similar to the effects of resistance exercise. The combination of hypoxic stress and resistance exercise is expected to have a greater effect on the improvement of muscular function and hypertrophy. Therefore, we examined the previous studies for understand the concept of intermittent hypoxic resistance training (IHRT) and its effectiveness, and to grasp the principle of IHRT to improve muscular function and hypertrophy. However, few investigations have examined the combination effects of hypoxic stress and resistance exercise, and as such it is difficult to make recommendations for implementing IHRT based on current understanding. It should also be acknowledged that a number of mechanisms proposed to facilitate the augmented response to IHRT remain poorly understood, particularly the systemic role of metabolic, hormonal, cellular swelling, and intracellular signaling pathways. Future research should examine the various physiological and biochemical mechanism and performance to resistance exercise in hypoxic condition and training in systemic hypoxic condition.
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