Abstract
The aim of experiments was to study the effect of hypocalcaemia on renal function changes in
 intragastric and subcutaneous administration of ammonium molybdate. The experimental hypoparathyroidism
 was modeled by removal of parathyroid glands in narcotized and immobilized rats by electrotermocauter
 under thiopental anesthesia. 30 days after the operation calcium concentration in blood was measured
 and individuals with most severe hypocalcaemia were selected. Ammonium molybdate was introduced
 intragastrally and subcutaneously at a does of 50 mg |kg daily for 30 days. Studies showed that subcutaneous
 administration of molybdenum on the background of hypoparathyroidism was associated with more
 severе renal impairment. Spontaneous urine output increased as a result of the oppression of the relative
 tubular reabsorption of water, while the glomerular filtration rate decreased. Protein excretion was increased
 in all groups with the introduction of ammonium molybdate with respect to baseline values, but the most
 severe proteinuria was noticed in the group with subcutaneous administration of ammonium molybdate in
 the background parathyroidectomy. Excretion of all studied cations (potassium, sodium, calcium) with urine
 increased. Histology of the kidneys revealed more pronounced signs of nephropathy.
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