Abstract
The age changes the endothelial hyperpolarization induced by the activation of Ca 2+-sensitive K+-intermediate conduction channels (IKca) and NO contribution in the pial arterial acetylcholine-mediated dilation in rats was studied. Using the method of intra vital microphotography (x470), a comparative assessment of the pial arterial reactions to acetylcholine (ACh, 10-7 M, 5 min) was carried out with and without inhibition of IKCa-channels (clotrimazole, 10-5M) and NO (L-NAME, 10-3M) in Wistar on 4 and 26 month old rats. About changing role of endothelial hyperpolarization and NO judged by the change in the number and degree of the arteries dilation on ACh after inhibition in 3 separate arteries groups: small (diameter less than 20 microns), medium (20-40 microns) and large (more than 40 microns). It was found that with age in rats, the contribution of endothelial hyperpolarization, induced by activation of IKca channels, to the small pial arteries dilation on the ACh, decreases. At the same time, the role of this mechanism in arteries of medium diameter increases. Changes in the vasodilation mechanisms during aging are probably associated with an age-related decrease in the number of small arteries and an enhanced role for NO-mediated regulation of endothelium-dependent dilator reactions.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
