Abstract
GABA(A) receptors are the major sites of fast synaptic inhibition in the central nervous system. To date 19 subunits have been identified (α1-6, β1-3, γ1-3, δ, e, π, 6 and ρ 1-3). These subunits form heteropentamers usually consisting of two a, two β and one γ subunits. This review focuses on the description of the GABA(A) biosynthesis and trafficking to the cell membrane. The emphasis of this work lies on the multiple layers of regulation and control of GABA(A) receptors biosynthesis and trafficking. Abnormalities in these processes cause various disorders including schizophrenia, alcoholism and substance abuse, anxiety disorders and epilepsy. The review also points to the areas that require further investigation.
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