Abstract
Objective. To study the dynamics of change in psycho-emotional and cognitive indicators in reproductive-aged women receiving a combined oral contraceptive (COC) with estetrol/drospirenone. Patients and methods. A prospective open-label observational study included 64 patients aged 18 to 45 years who applied for contraception selection. According to the study protocol, all patients underwent general clinical examination at baseline, 3 and 6 months from the start of COC administration. The examination included calculation of body mass index (BMI) by Brey formula, measurement of blood pressure, transvaginal ultrasound, assessment of psycho-emotional state and cognitive function. Results. The data obtained in this study indicate a positive effect of COC containing estetrol/drospirenone on the psychoemotional state and cognitive function in patients, which is characterized by increased levels of physical activity regardless of age, decreased levels of anxiety and depression, greater satisfaction with sleep quantity and quality, improved cognitive function due to a positive effect mainly on mild cognitive disorders. Conclusion. Current data on the neuroprotective effect of estetrol in relation to the central nervous system require further study and comprehension. Key words: psycho-emotional state, cognitive disorders, combined oral contraceptive, estetrol, drospirenone
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