ДИНАМИКА ПОКАЗАТЕЛЕЙ ЛИНОЛЕВОЙ И АРАХИДОНОВОЙ ЖИРНЫХ КИСЛОТ В КРОВИ ПУПОВИНЫ НОВОРОЖДЕННЫХ ОТ МАТЕРЕЙ С ЦИТОМЕГАЛОВИРУСНОЙ ИНФЕКЦИЕЙ

Abstract

Due to the broad spectrum of influence of polyunsaturated fatty acids of ω-6 family on the development of the fetus and newborn child, the composition of arachidonic fatty acid and its predecessor linoleic fatty acid were studied in blood of the umbilical cord blood of newborns from mothers with chronic reactivation of cytomegalovirus infection. 82 newborns were examined; among them there were 42 infants (the main group) from mothers who had cytomegalovirus infection (titer of IgG antibodies to cytomegalovirus was 1:1600) in the III trimester. The control group included 42 newborns from healthy women. In the umbilical cord blood of newborns the contents of arachidonic and linoleic fatty acids were identified with gas-liquid chromatography. The study found out that the reactivation of cytomegalovirus infection in the mother (titer of IgG antibodies to cytomegalovirus 1:1600) leads to an increase in the content of linoleic acid by 56% (p<0.001) and of the predecessor of pro-inflammatory eicosanoids - arachidonic acid by 34% (p<0.001) in the cord blood of newborns; it is one of the causes of disturbance of the structural and functional organization of the umbilical artery vessels. Identified changes in umbilical cord blood and umbilical artery endothelium can cause disturbances of the elastic properties of vessels, stagnation and thrombosis of blood vessels and, consequently, disturbances of blood flow between mother and fetus, which can then serve as a factor in the development of fetal hypoxia.