ОЦЕНКА ИНТЕНСИВНОСТИ СВОБОДНО-РАДИКАЛЬНЫХ ПРОЦЕССОВ ПО ИЗМЕНЕНИЮ КОНЦЕНТРАЦИИ МАЛОНОВОГО ДИАЛЬДЕГИДА ПРИ РАЗЛИЧНЫХ СПОСОБАХ ПАРЕНТЕРАЛЬНОГО ВВЕДЕНИЯ ЛЮМИНОЛА

Abstract

Assessment of the intensity of free-radical processes that change their activity in response to exogenous and endogenous intoxication is carried out by biochemical methods of determining the state of the antioxidant system of the body (AOS). This is a complex of methods, one indicator of which is the level of lipid peroxidation by accumulation of malondialdehyde (MDA). Revealing certain features of the mutually regulating influence of the processes of lipid oxidation and antioxidant system of the body may serve as a criterion for evaluation and prognosis of the course of the pathological process in endogenous toxicity and correction of therapeutic tactics. Peroxidation in the elderly and old age is of particular importance, since there is still no definitive opinion on the dynamics of the physiological course of lipid peroxidation in this age group, the criteria for the transformation of peroxidation reactions from normal to pathogenic. In this work we evaluated the antioxidant activity and duration of the preservation effect on the antioxidant protection of the organism of the drug "Tameron" (sodium luminol) with different methods of parenteral administration in the model of age-related lower primates. At intramuscular and intravenous injection of the drug "Tameron" in experimental animals a marked decrease in the concentration of MDA in blood plasma was observed. This suggests a decrease in the activity of peroxidation processes and activation of antioxidant protection of the body, which is especially important in age-matched animals. It should be noted the preservation of low indicators of oxidative stress indicator in the representatives of the experimental group for a long time period (about a year) and suggest a pronounced antioxidant prolonged effect of the studied preparation, accompanied by alignment of MDA concentration throughout the group to statistically similar values.