Влияние токсичных продуктов горения на состояние микробиоты кишечника у пожарных в патогенезе неалкогольной жировой болезни печени

Abstract

Medical and psychological support of professional activity of firefighters does not take into account their chronic poisoning by toxic products of burning. Such diagnoses are made to the firefighters of the State Fire Service of the Federal Fire Service of EMERCOM of Russia only in case of acute poisoning. Insufficient attention paid to the impact of fire-specific toxicants, including dioxins, does not allow timely detection of disturbances in the regulation of physiological systems of firefighters’ organisms, which leads to the emergence of diseases. The aim of the study was to determine the effect of dioxins on the state of the microbiota. Materials and research methods. The study involved 246 male patients, of whom 121 were employees of the State Fire Service of the Federal Fire Service of EMERCOM of Russia and 125 were civilians and rescuers of EMERCOM of Russia. Research results and their analysis. The data obtained in the study of the blood microbiota by chromatography-mass spectrometry of microbial markers indicate a pronounced intestinal dysbiosis in firefighters with non-alcoholic fatty liver disease due to decreased number of microbial markers of the normal microbiota along with increased total number of microbial markers and opportunistic microorganisms. The dysbacteriosis revealed in the firefighters having no health complaints can be a predictor of liver pathology development that testifies to necessity of control and timely correction of microecological status.