Результаты лечения хронической боли в области плечевого пояса с применением препаратов на основе полинуклеотидов и коллагена

Abstract

Aim: to evaluate the efficacy and safety of intra- and peri-articular administration of injectable gel implant containing polynucleotides and collagen implants in patients with adhesive capsulitis / impingement syndrome / cervical spondylosis (uncovertebral arthrosis, spondylosis) with clinical reflex and reflex compression signs and orthopedic conditions. Patients and Methods: this prospective multicenter longitudinal 6-month study included 100 men and women (mean age 45 years). The patients were divided into 4 groups (25 patients in each group) based on the diagnosis. Treatment strategy (intra- and peri-articular administration of injectable gel implant containing polynucleotides and collagen implants) was determined by diagnosis and joint inflammation. Before and after treatment, the functional state of the shoulder and pain severity were assessed using questionnaires and laboratory and instrumental tests. Efficacy was assessed by pain relief, improvement in the functional activity of the shoulder joint, and changes in the range of movements in the shoulder joint and cervical spine. Treatment safety was assessed by the adverse effects. Results: after treatment, most patients reported an increase in the range of movements in the cervical spine and shoulder joint, a decrease in pain severity in the cervical spine and shoulder joint, and improvement in the functionality of the shoulder joint. After treatment, a decrease in the CRP levels and ESR was observed. No severe adverse effects were detected. Conclusion: intra- and peri-articular administration of gel implant containing poly-nucleotides and collagen implants for upper shoulder girdle disorders is effective and safe. KEYWORDS: upper shoulder girdle, cervical spine, shoulder joint, chronic pain, polynucleotides, collagen, collagen implant, intraarticular injection, periarticular injection. FOR CITATION: Shcherbakov G.I., Kovtun S.N., Potkina T.N. Outcomes of treatment for chronic shoulder pain using drugs containing polynucleotides and collagen. Russian Medical Inquiry. 2024;8(2):102–109 (in Russ.). DOI: 10.32364/2587-6821-2024-8-2-8.