Психовегетативные особенности и клинические проявления при различных фенотипах недифференцированной дисплазии соединительной ткани у военнослужащих по призыву

Abstract

The aim of the study is determined the phenotypes and the features of clinical manifestations of conscripts with undifferentiated connective tissue dysplasia (CTD). Materials and methods. Examined 118 men 18-25 years, conscripts, who had no acute diseases. External signs of CTD were determined and CTD phenotypes were diagnosed on the basis of modern Russian recommendations. The study group consist of men with 6 or more external signs, the control group consist of men with less than 6 signs. Evaluated the Hospital anxiety and depression scale (HADS), visual analogue scale (VAS) of pain, scale of asthenic condition, Vein Questionnaire of autonomic dysfunction. Results. Among the 118 surveyed 6 or more of CTD were detected in 74 (62.7%). Was following phenotypes: unclassified - 22 (29,7%), marfanoid appearance - 10 (13,5%), the joint hypermobility syndrome - 8 (10,8%), the combination of marfanoid appearance and joint hypermobility syndrome -7 (9,5%), increased external stigma - 7 (9,5%), increased visceral stigma - 6 (8,1%) and others. The CTD group (n=74) did not differ from the control group by age and sex, but had higher growth and hand span and lower body mass index values. found There are higher scores of HADS anxiety scale, fatigue and scores on Vein Questionnaire in the CTD group. Subjects with CTD showed more pronounced pain in the joints, back and heart. Conscripts with CTD tended to extend the QT interval on ECG (p=0.079) and lower end diastolic volume. Conclusion. CTD was diagnosed in 62.7 % of the conscripts (n=118). The most frequently recorded the unclassified phenotype, marfanoid appearance and joint hypermobility syndrome. Men with CTD had lower BMI values, more severe performance anxiety, asthenia, autonomic disorders, joints pain, back pain and heart pain and lower end-diastolic volume.