Особенности секреции ростовых факторов эозинофильными гранулоцитами крови при раке желудка и толстого кишечника с тканевой эозинофилией

Abstract

We analyzed in vitro secretion of growth factors (TGFβ1, VEGF, and EGF) by peripheral blood eosinophil granulocytes in patients with gastric and colon cancer according to the presence of tumor-associated tissue eosinophilia. In gastrointestinal cancer with tissue eosinophilia, an increase in basal in vitro secretion of TGFβ1 and VEGF (in gastric cancer) was detected, while basal eosinophil-derived EGF production in gastric and colon cancer did not differ significantly from that in the comparison group (without tissue eosinophilia). Additionally, it was shown that in patients with gastric cancer and colon cancer, regardless of the presence of tissue eosinophilia, the levels of basal and r-IL-5-induced secretion of TGFβ1, VEGF, and EGF by eosinophil granulocytes in vitro were comparable. An absence of the secretory response of eosinophils to cytokine stimulation (by r-IL-5) indicates a decrease in the functional reactivity of the cells.