Исследование механизмов ремоделирования миокарда левого желудочка у пациентов с метаболическим синдромом и обструктивным апноэ во сне

Abstract

The dynamics of the main echocardiographic parameters of left ventricular myocardium (LVM), reflecting the mechanisms of myocardial remodeling of left ventricle in patients with metabolic syndrome and sleep obstructive apnea syndrome (SOAS) was studied. The research involved 98 men who are overweight (BMI > 30 kg/m 2 ) with established earlier a diagnosis of hypertension and blood pressure stabilization achieved against a background of adequate medical therapy. Study participants underwent cardiorespiratory monitoring night’s sleep for diagnosis of sleep obstructive apnea syndrome with assessment of apnea/hypopnea index and average nocturnal saturation, and EchoCG was performed to assess the structural parameters of LVM, such as left ventricle (LV) diameters, the thickness of the interventricular septum and posterior wall of LV with further calculation of LVM mass index. The data revealed reliable correlation of left atrium length and thickness of the left atrial posterior wall with an index of apnea/hypopnea (р < 0.05). No significant association study of structural parameters of LVM with the level of nocturnal hypoxemia have been identified. The study conclusions were drawn about the likely impact of the periodic independent upper airway obstruction in the remodeling of the left ventricle in the absence of a direct influence on the process of remodeling nocturnal hypoxemia.