보조적 항암화학요법 주기동안 운동프로그램의 실시가 대장암 환자의 신체조성, 우울 및 치료 관련 독성 부작용에 미치는 영향

Abstract

Purpose: The purpose of this study is to compare and analyze the effects of the exercise program on body composition and treatment related toxicities of the colorectal cancer patients during the adjuvant chemotherapy cycle to provide important basic data for the development and dissemination of a customized exercise program for colorectal cancer patients.BR Method: With thirteen patients with stage 2-3 colorectal cancer who had to undergo adjuvant chemotherapy were sampled as subjects (exercise group: 7 patients, non-exercise group 6 patients), an exercise program was conducted during the adjuvant chemotherapy period to compare and analyze changes in body composition, treatment related toxicities, and depression. The 50-minute exercise program consists of 10 minutes of warm-up exercise, 30 minutes of the main exercise, and 10 minutes of cool-down exercise. The main exercise was performed as a aerobic and anaerobic exercise the intensity was set at RPE 12~17.BR Results: As a result of two-way repeated-measures ANOVA, which was conducted to explore the effects of group and measurement period on body composition and depression during adjuvant chemotherapy, muscle mass(kg)(F=3.589, P=.000), lean mass(kg)(F=3.529, P=.000), skeletal muscle mass(kg)(F=3.072, P=.001), body fat mass(kg)(F=4.530 P=.017) visceral fat area(cm²)(F=3.734, P=.024), waist hip ratio(%)(F=3.026, P=.032) showed the main effect at the time of measurement. Furthermore, in muscle mass(kg)(F=2.784, P=.003), lean mass(kg)(F=2.754, P=.003), skeletal muscle mass(kg)(F=2.613, P=.005), there was a significant difference in the interaction effect for the group and the measurement period. In treatment-related toxicities of 0-1 grade were shown in Nausea, Neuropathy-Sensory, and Pain from Cycle 1 to Cycle 12 in the exercise group, and no grade 2 or higher side effects were shown. The non-exercise group showed side effects of grades 0-1 only in pain from cycle 1 to 12.BR Conclusion: The results of this study confirmed that the exercise program for colorectal cancer patients receiving adjuvant chemotherapy positively affected body composition, depression, and treatment related toxicities during chemotherapy. As the incidence of cancer increases worldwide and more patients are expected to experience chemotherapy, research on exercise for various types of cancer other than colorectal cancer should be continued.