Abstract
In the article we present the results of estimating the phagocytic activity and priming effect in the polymorphonuclear leukocytes of blood under the effect of Streptococcus pyogenes complex antigen in patients having acute purulent inflammatory diseases of skin and soft tissues against the background of type 2diabetes (with diabetic foot syndrome) and without it. The examination of patient's blood was performed by the method of barium sulfate-stimulated luminol-amplified chemiluminescence. On the basic of the obtained results it has been found out that the patients with diabetic foot syndrome had the reduction in phagocytic activity and priming effect of polymorphonuclear leukocytes as compared to the patients with no carbohydrate metabolism disorders. The significant negative correlation between phagocytic activity, priming effect in the polymorphonuclear leukocytes and blood hyperglycemia in diabetic foot syndrome was detected.
Highlights
Evdokimov Moscow State University of Medicine and Dentistry, Moscow In the article we present the results of estimating the phagocytic activity and priming effect in the polymorphonuclear leukocytes of blood under the effect of Streptococcus pyogenes complex antigen in patients having acute purulent inflammatory diseases of skin and soft tissues against the background of type 2diabetes and without it
On the basic of the obtained results it has been found out that the patients with diabetic foot syndrome had the reduction in phagocytic activity and priming effect of polymorphonuclear leukocytes as compared to the patients with no carbohydrate metabolism disorders
White blood cell count is associated with macro- and microvascular complications in Chinese patients with type 2 diabetes // Diabetes Care. – 2004. – Vol 27, N 1. – P. 216-222
Summary
В статье оценивали фагоцитарную активность и эффект прайминга полиморфно-ядерных лейкоцитов крови (ПМЛ) при воздействии комплексного антигена Streptococcus pyogenes у пациентов с острыми гнойно-воспалительными заболеваниями кожных покровов и мягких тканей на фоне сахарного диабета II типа (с синдромом диабетической стопы) и без него. Что у пациентов с синдромом диабетической стопы наблюдается снижение фагоцитарной активности и ослабление эффекта прайминга ПМЛ крови по сравнению с пациентами, не имеющими нарушения углеводного обмена. Of A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow In the article we present the results of estimating the phagocytic activity and priming effect in the polymorphonuclear leukocytes of blood under the effect of Streptococcus pyogenes complex antigen in patients having acute purulent inflammatory diseases of skin and soft tissues against the background of type 2diabetes (with diabetic foot syndrome) and without it. The significant negative correlation between phagocytic activity, priming effect in the polymorphonuclear leukocytes and blood hyperglycemia in diabetic foot syndrome was detected. Цель исследования: оценить фагоцитарную активность ПМЛ периферической крови и их праймирующую способность при воздействии Streptococcus pyogenes у пациентов с гнойно-воспалительными осложнениями при СДС
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