Метаболічний потенціал лейкоцитарної та тромбоцитарної субпопуляцій клітин периферичної крові та його корекція у хворих на вугрову хворобу

Abstract

Objective – to increase the effectiveness of treatment of patients with acne, taking into account the peculiarities of the metabolic activity of leukocytes and peripheral blood platelets through the use of pathogenetic therapy. Materials and methods Under our supervision there were 66 patients with acne (39 women and 27 men) aged 18 to 40 years. The duration of the disease ranged from 6 months. up to 14 years old. 42 (63,6%) patients were diagnosed with a mild degree of severity of the course of dermatosis, and in 24 (36,4%) – moderate. In most patients, the pathological process covered two or three topographic areas, that is, it tended to spread. The content of phospholipids and glycogen in neutrophils, monocytes and platelets of peripheral blood was determined by calculating the average cytochemical coefficient (MCC). The control group consisted of 20 healthy individuals. Results and discussion It is proved that in patients with acne there is a probable decrease in the level of phospholipids in peripheral blood neutrophils, which is more pronounced in the moderate severity of the pathological process. The obtained data indicate, respectively, a violation of the structural integrity and inhibition of the energy potential of granulocytes. The content of phospholipids in peripheral blood monocytes was also likely to decrease, more significantly at moderate severity of acne. However, the vector of changes in glycogen levels in these cells had the opposite direction. The results led us to the adjuvant use of platelet-enriched autoplasma, which has a wide range of modulating effects. Conclusions It has been found that in patients with acne, there are various vector changes in the metabolic activity of peripheral blood monocytes, which are manifested by a decrease in phospholipids, combined with an increase in glycogen content, which characterizes the development of intracellular imbalance. It was determined that the metabolic activity of the platelet pool of peripheral blood in acne remains intact, but there is a redistribution of the number of hemoelements with different saturation of phospholipids and glycogen. It is proved that the use of complex therapy of patients with acne using, against the background of standardized drugs, autoplasma enriched with platelets, can significantly improve both short-term and long-term treatment results by significantly correcting the metabolic activity of peripheral blood leukocytes.