Abstract
The study was aimed to investigate the role of support afferentation in support of functioning the signaling mechanisms responsible for slow-type oxidative genes expression during postural soleus muscle unloading. For the investigation of the support afferentation the plantar mechanical stimulation was used. Male Wistar rats were divided into six groups (8 animals in each): two cage control groups (C), two groups hindlimb unloaded for 1 day or 3 days (1 HS, 3HS) and two hindlimb-unloaded groups with plantar mechanical stimulation 1HS+МСО; 3HS+МСО. Animals from stimulated groups received plantar stimulation during 4 hours a day, mimicking the pattern of normal animal walking. Plantar mechanical stimulation led to prevention of slow myosin I(β) and myh7b mRNAs expression decreases after 1 day of unloading. After three days of hindlimb unloading the expression of slow myosin I(β) mRNA and myh7b mRNA significantly increased in plantar stimulated group, and the expression of SOX6 mRNA in this group did not differ from control, although it was significantly increased in pure unloaded group. So, plantar mechanical stimulation prevents unloading-induced MyHC I/myh7b/SOX6 inactivation, inhibiting slow-to-fast fiber-type shift.
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