АБДОМИНАЛЬНАЯ АТАКА В ДЕБЮТЕ НАСЛЕДСТВЕННОГО АНГИООТЕКА У ДЕВУШЕК С ПЕРВИЧНОЙ ДИСМЕНОРЕЕЙ НА ФОНЕ ТЕРАПИИ КОМБИНИРОВАННЫМИ ОРАЛЬНЫМИ КОНТРАЦЕПТИВАМИ

Abstract

Hereditary angioedema (HAE) is an orphan potentially life-threatening disease characterized by recurrent edema of the skin, mucous/submucosal membranes and is genetically determined. In most cases, there are peripheral edemas and manifestations of marginal erythema at the onset of the disease, much less often - abdominal syndrome. Among patients with HAE, there is a clear predominance of women. In this regard, girls in puberty with primary dysmenorrhea and various menstrual disorders are of particular interest. In the treatment of adolescent girls suffering from these nosologies, combined oral contraceptives (COCs) are often used. The debut of manifestations of HAE in the form of severe abdominal attacks in girls with dysmenorrhea during COC therapy has not yet been described. The article presents descriptions of cases of patients with the outset of HAE in the form of abdominal attacks that developed against the background of treatment of primary dysmenorrhea with COCs. The importance of awareness of pediatricians, pediatric surgeons, gynecologists and doctors of other profiles about this nosology is demonstrated using the examples of these clinical cases’ data.