Abstract
The research was performed to investigate the possibility of stimulating reparative processes in rats with acute focal cerebral ischemia (AFCI) by administering the cryopreserved cord blood serum (CCBS) of human. A comparative morphometric analysis of the structural components of the cerebral cortex sensor-motor area was conducted in dynamics of treatment. The development of a potent neurotoxic effect during the AFCI was confirmed by qualitative and quantitative indices, in particular by the 4.57 times increase of alterational and in 3.62 times of the perineural satellite indices relative to the control. Degenerative processes were accompanied with powerful microcirculatory changes associated with the brain tissue swelling, as evidenced by a rise in average area of perivascular spaces by 45 times versus intact animals and pronounced secondary spasm of the vessels. The use of CCBS stimulated reparative processes in the necrotic zone by increasing the capillary density by 21.8% if compared to intact animals and prevented the development of the blood-brain barrier and membrane-receptor complex dysfunction. Probl Cryobiol Cryomed 2019; 29(3): 277–290.
Highlights
The research was performed to investigate the possibility of stimulating reparative processes in rats with acute focal cerebral ischemia (AFCI) by administration of human cryopreserved cord blood serum (CCBS)
The findings have shown that on day 7 after the rats with the simulated AFCI were administered with the CCBS the area of perivascular edema decreased by 21.4%, whereas for the animals of group 2 that was only by 12.7%
Impaired cerebral circulation in experiment causes a strong neurotoxic effect, characterized by varying degrees of structural and functional impairment of neurons and cells of neuroglia, which confirmed by such qualita tive and quantitative indices as the alteration (4.57-fold increase versus group 1) and perineuronal satellite (3.62-fold increase versus group 1) indices
Summary
The research was performed to investigate the possibility of stimulating reparative processes in rats with acute focal cerebral ischemia (AFCI) by administration of human cryopreserved cord blood serum (CCBS). The CCBS has been shown to have a positive effect when tertaing the brain lesions caused by AFCI. Використання факторів росту та біологічно активних речовин досить поширене у сучасній медицині. У межах такої терапії хворий отримує біологічно активні сполуки природного походження, які здатні впливати на різні ланки метаболізму та стимулювати репаративні процеси. Але даних щодо використання факторів росту та біологічно активних речовин, зокрема раннього онтогенезу, які можуть стимулювати репаративні процеси за умов гострої фокальної церебральної ішемії (ГФЦІ), на сьогоднішній день недостатньо
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