Роль родительских и персональных факторов риска в формировании гипертрофии глоточной миндалины у детей раннего и дошкольного возраста

Abstract

Pharyngeal tonsil hypertrophy of the second and higher degree occurs in infants and preschool children with the frequency of 5% and higher. The issue of exogenous and endogenous factors contributing to the formation of pharyngeal tonsil hypertrophy in infants and preschool children remains relevant for the modern pediatrics. Adenotomy surgery cannot be performed with the same frequency, because it has intraoperative, early post-operative and long-term complications and consequences. The search for parental and personal controlled risk factors of formation of the pharyngeal tonsil hypertrophy is an urgent task for pediatrics and pediatric otorhinolaryngology. The objective of the study was to assess the role of parental and personal risk factors on the occurrence of pharyngeal tonsil hypertrophy in infants and preschool children. Materials and methods. The authors studied the extended medical history and DNA markers of pharyngeal biotope microorganisms in children with adenoid vegetations (228 children) and healthy children (63 children). The associations of social, medical, and microbiome predictors with the pharyngeal tonsil hypertrophy were studied using multi-analysis. Results. It was revealed that the formation of the pharyngeal tonsil hypertrophy is associated with integrative parental and personal risk factors, as well as with the high expression of Streptococcus pyogenes and Epstein–Barr virus in the pharyngeal biotope. The prescription of antibacterial and antiviral therapy in the treatment of acute respiratory disease in children with the pharyngeal tonsil hypertrophy should be made taking into account the expression of Streptococcus pyogenes and Epstein–Barr virus.