Abstract
The objective: was to study the effectiveness of stimulation of ovulation in women with tuboperitoneal infertility, depending on the drug used. Materials and methods. To achieve this goal, 239 patients with tuboperitoneal infertility were examined, which were randomly divided into two groups I (main, n=118) and II (comparisons, n=121). Women of the main group for KOS were prescribed a single subcutaneous injection of corypholitropin alfa into the abdominal wall at the beginning of the follicular phase of the menstrual cycle at a dose of 150 μg. Women in the comparison group received daily injections of follitropin beta 150–225 IU for 6–12 days. After denudation the maturity and quality of the eggs was evaluated. Results. The average duration of superovulation stimulation in women of the main group was 8.43±0.01 days, and in the comparison group 10.51±0.03 days (p<0.05). The number of obtained oocytes was 17.68±0.51 in group I, 14.58±0.25 in group II (p<0.05); mature oocytes 14.35±0.24 and 10.16±0.19 respectively (p<0.05). When analyzing the quality of oocytes, it was determined that 77.78% of mature eggs were obtained in the I group, and 62.5% – in the II group (p<0.05). Among mature oocytes in both groups only in two thirds of cases (74.15% and 69.0%; p<0.05) they were of high quality, while in the other there were some changes in their structure. Conclusion. Optimal for young women with tuboperitoneal infertility is a short COS protocol using prolonged-action rFSH, which allows to get more high-quality oocytes with reduction the stimulation period. Key words: tuboperitoneal infertility, in vitro fertilization, stimulation of superovulation, follicle-stimulating hormone, oocyte.
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