РЕЗУЛЬТАТЫ ЛЕЧЕНИЯ ЛОКАЛЬНОГО РЕЦИДИВА И ПРОДОЛЖЕННОГО РОСТА МЕЛАНОМЫ СОСУДИСТОЙ ОБОЛОЧКИ ГЛАЗА У ПАЦИЕНТОВ С ИСПОЛЬЗОВАНИЕМ ФОТОДИНАМИЧЕСКОЙ ТЕРАПИИ

Abstract

Background. The proportion of recurrence and continued growth (RC) of choroidal melanoma after organ- preserving treatment is 19%. Purpose. To perform a comparative assessment of the results of treatment of patients with RC of choroidal melanoma using photodynamic therapy (PDT) in comparison with brachytherapy (BT) and enucleation. Material and methods. Data from the Belarusian Cancer Registry of 60 patients with RC melanoma of the choroid for the period from February 2009 to November 2020. The average age is 65.3±13.17 years. For PDT, a photosensitizer "Photolon" was used, with the action of a laser device "UPL-PDT" with a wavelength of 665±5 nm, with a dose to the tumor surface of 100 kJ / cm2. Results. After 1 course of PDT, the tumor resorbed in 5 patients. 15 has stabilization with residual tumor tissue h=1.8±1.4 mm; l=6.05±3.4 mm. Median visual acuity (VA) – 0.1 (IQR 0.05-0.2). After BT, the tumor resorbed in 13 patients. 7 registered stabilization with h=0.15 (IQR 0.05-0.2 mm); l=0 (IQR 0-6.07 mm). The median VA was 0.03 (IQR 0.01-0.09). The overall 5th disease-free survival rate in the three groups was 43.2±6.9%. The overall 5-year survival rate with organ-preserving treatment was 100% in the groups after PDT and BT and 94.7±5.1% after enucleation. Conclusions. PDT allows you to preserve residual vision in patients in comparison with radiation therapy. The results of the analysis of recurrence-free survival in patients with RC of choroidal melanoma make it possible to give preference to organ-preserving methods of treatment.