Эффективность растительного лекарственного препарата в лечении и иммунореабилитации детей раннего и дошкольного возраста с повторяющимися острыми назофарингитами

Abstract

Objective. To assess the efficacy of herbal medicine (HM) in the treatment and immunorehabilitation of children aged 2–6 years with recurrent acute nasopharyngitis. Patients and methods. This study included 327 children aged between 2 and 6 years; 85 of them were healthy and comprised the control group. The remaining children (n = 242) were divided into two groups by simple calendar randomization: the group receiving HM (n = 133) and the group receiving standard treatment (n = 109). All children have undergone the following examinations 45 days following treatment initiation: clinical examination, complete blood count, measurement of total IgE in peripheral blood, rhinocytogram, assessment of nasopharyngeal lavage and cells from the mucous membrane of the posterior wall of the oropharynx. Nasopharyngeal lavage was tested using enzyme-linked immunosorbent assay (ELISA) for the level of cytokines, including interleukins-1β and 4 (IL-1β, IL-4), interferons-α and -γ (IFNa, IFNy), and tumor necrosis factor-α (TNFα).DNA was isolated from the cells of the pharyngeal mucosa and pharyngeal tonsil and for subsequent analysis of the local biotope: bacteria, viruses, and fungi. Results. We found that HM helped to reduce clinical manifestations of acute nasopharyngitis, reduced local inflammation after treatment, and decreased the concentration of opportunistic flora, including Staphylococcus aureus. Conclusion. The inclusion of HM in the treatment regimen for children with recurrent nasopharyngitis increases treatment efficacy and prevents relapses. Key words: nasopharyngitis, immunorehabilitation