Abstract
95 men aged 45-65, suffering from type 2 diabetes for 0.1-20 years (4.5 +/- 1.4) were examined. Hypoandrogenia (serum testosterone < 10,4 nmol/ml) was noted in 37% of investigated patients. Hyperuricemia (HUA), defined by serum uric acid (UA) content more than 450 pmol/L, was detected in 34% of subjects. In 74% of patients there was a high level of 24h UA urine excretion (UA(u) > 4.43 mmol), suggesting a hyperproduction of UA. Because the level of uricemia is defined by UA production and extretion, we outline two main types of alterations in UA metabolism: normouricemic, hyperuricosuric and hyperuricemic. In normouricemic and hyperuricosuric men UA excretion growth in parallel with the rate of kidney filtration, obesity, glycemia. High urate elimination index (UEI) suggests a decrease of UA reabsorption in kidney. The results allow us to suggest a significance of insulin and testosterone influence on regulation of UA metabolism in aged men with type 2 diabetes and insulin resistance syndrome.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
