СРАВНИТЕЛЬНАЯ ХАРАКТЕРИСТИКА ПОЧЕЧНОГО КРОВОТОКА У БОЛЬНЫХ ХРОНИЧЕСКОЙ ПОЧЕЧНОЙ НЕДОСТАТОЧНОСТЬЮ, РАЗВИВШЕЙСЯ ВСЛЕДСТВИЕ МИЕЛОМНОЙ НЕФРОПАТИИ И ПРИ ПЕРВИЧНОЙ НЕФРОЛОГИЧЕСКОЙ ПАТОЛОГИИ

Abstract

A comparative analysis of the indicators of renal hemodynamics in patients with chronic renal failure/chronic kidney disease (CRF/CKD) developed against myeloma nephropathy (group 1) and with primary kidney disease (group 2) was done. 20 patients were included in the first group, 14 patients were in the second one, and in most cases there was Stage 3 CRF/CKD. There were analyzed the following indicators of renal blood flow: peak systolic velocity, end diastolic velocity, mean flow velocity throughout the entire cardiac cycle, resistive index and pulsation index. Circulation figures were recorded at the level of basic, segmental, interlobar, arc, interlobular renal arteries. It is concluded that violations of renal blood flow and vascular resistance in patients with multiple myeloma complicated by chronic renal failure are primarily due to CKD itself. The differences in the two groups of patients with CRF/CKD were only about the average level in the parenchymal blood flow velocity (interlobular, arcuate, interlobar arteries); at myeloma nephropathy it was significantly reduced in comparison with the control group and patients with CRF/CKD without hemoblastosis. The rest velocity parameters were significantly reduced and vascular resistance indices were increased in comparison with the control and did not differ in groups of patients with CRF/CKD. Thus, hemodynamic changes at the level of parenchyma are the most important for patients with multiple myeloma, which suggests more severe violations of kidneys in these patients with the complication of CRF.