Abstract
The authors have examined 30 patients with essential hypertension combined with diabetes mellitus of type 2 in the dynamics of treating with a combination of antihypertensive agents (S-amlodipine and lisinopril) with metformin or pioglitazon. It has been established that treating with antihypertensive drugs with metformin and pioglitazon is accompanied with a significant decrease of the fibrinogen level, an elevated activity of antitrhombin III and Hagemann’s dependent fibrinolysis, an increase of the potential activity of plasminogen (in the subgroup of metformin), a decrease of the indices of the lysis of low- and high-molecular proteins without changes of the blood collagenolytic activity.
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