Abstract
The article presents the results of a pilot study of the role of the oxidative modification of temporal bone tissue proteins in 109 patients with chronic otitis media after reconstructive sanitizing otosurgery. The improvement of surgical treatments methods using autografts to compensate for hearing loss and remove a purulent focus in the middle ear cavity does not always result in persistent remission of chronic inflammation, which explains the search for new aspects of chronic otitis media pathogenesis. The triggers of the pathological process activity are the indicators of oxidative stress in the bone structures of the middle ear. For comparison, the authors studied the changes in the protein composition of bone tissue, reflecting a disorder of the temporal bone structures remodeling processes in chronic inflammation of the middle ear cavities depending on the date of primary visit up to the otosurgery date. The obtained data made it possible to establish qualitative and quantitative changes in the oxidative modification of the temporal bone tissue proteins in the patients with chronic otitis media at various periods of the disease.
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