ДИНАМИКА ЛЕЙКОЦИТАРНЫХ ИНДЕКСОВ В КРОВИ ЦЫПЛЯТ КРОССА «ХАЙСЕКС БРАУН» ПОСЛЕ ПРИМЕНЕНИЯ РАЗНЫХ ДОЗ ЭНРОФЛОКСАЦИНА В УСЛОВИЯХ ЭКСПЕРИМЕНТАЛЬНОГО САЛЬМОНЕЛЛЕЗА

Abstract

Salmonellosis is a serious pathology of infectious origin, leading to high economic losses in poultry farming. A particular danger of the disease is that infected poultry may be a hidden bacterial carrier, and salmonellosis is also a threat to humans. For preventive, as well as therapeutic measures, antibacterial drugs are used, one of which is a representative of fluoroquinolones – Enrofloxacin. Despite the data on the good antimicrobial effect of the drug, little research has been conducted on its impact on the physiological condition of birds, in particular, the impact of Enrofloxacin on white blood. For the study four groups were formed, from which II and III received Enrofloxacin in doses of 200 mg/l and 100 mg/l, while I and IV – normal drinking water, and groups II, III, IV were experimentally infected with Salmonella infantis culture in the concentration of 30 million COE/0.5 ml. Blood samples were taken on the 1st, 3rd, 5th, 7th and 9th day after the drug withdrawal. The following parameters were studied: blood leukocyte content, leukocyte formula, and dynamics of leukocyte indices. The revealed changes in all experimental groups testify to the ambiguous antibacterial effect of the use of Enrofloxacin, although the use of 200 mg/l dosage, to some extent, was more effective. Nevertheless, on the whole, in spite of the revealed reliable shifts of the studied indicators in chickens of the experimental groups, no negative effect of the preparation on the cockerels' organism was revealed.