Этапы становления микробиоты желудочно‑кишечного тракта и роль пробиотиков в коррекции кишечной колики у детей первых месяцев жизни

Abstract

The physiologic microbiota of the GI tract performs many important functions that coordinate various processes, such as trophic, protective, anti-inflammatory, and immune functions. Transient enzymatic immaturity and immaturity of neuroendocrine regulation of GI motility in newborns creates prerequisites for gastrointestinal dysfunctions that increase with imbalance of the intestinal microbiome, represented by intestinal colic, increased gas formation, gastroesophageal and duodenogastric regurgitation. The objective of the study was to analyze the effectiveness of Probielle® Baby probiotic in the correction of intestinal colic and associated functional GI disorders in children of the first months of life. Patients and methods. The study included 88 children of the first 3 months of life, divided into 3 groups – two main groups receiving Probielle® Baby probiotic and a control group, in which only symptomatic therapy of intestinal colic was performed. The parameters of efficacy assessment included: daily monitoring of crying duration, assessment of stool frequency and consistency, severity of flatulence, frequency and nature of regurgitation, dynamics of intestinal microbiota composition. In order to determine the severity of the intestinal colic syndrome, a score was used. Results. In association with Probielle® Baby, the regression of intestinal colic was more pronounced, and fewer episodes of flatulence and proximal gastroesophageal regurgitation were also noted. Thus, the use of probiotics will significantly increase the effectiveness of complex therapy of gastrointestinal dysfunctions in newborns and children of the first months of life. Key words: microbiota, newborns, immunity, intestinal colic, Probielle Baby