Состояние гипоталамо-гипофизарно-надпочечниково-яичниковой системы у женщин с опухолями и опухолевидными образованиями органов репродуктивной системы в постменопаузальный период

Abstract

The objective: of the study was to study the state of the hypothalamic-pituitary-adrenal-ovarian system in women with benign preinvasive and tumor-like formations of the reproductive system organs in the postmenopausal period. Materials and methods. 130 women with various tumors and tumoral formations of reproductive system organs in the postmenopausal period were examined. The parameters of follicle stimulating, luteinizing hormones, estradiol, estrone, prolactin, progesterone, testosterone, dehydroepiandosterone sulfate were studied. Results. It was established that out of 130 women with various tumors and tumoral formations of the organs of the reproductive system in the postmenopausal period, uterine myoma was defined in 39 (39%), endometrial hyperplasia in 23 (17.7%), tumor-like formation of ovaries in 17 (13.1%). It was found that in the postmenopausal period, the presence of hyperandrogenia, hyperprolactinemia, and a significant increase in the level of estrone were noted in women with benign, preinvasive and tumor-like formations of the organs of the reproductive system, regardless of tumor origin. Conclusion. The obtained results allowed to conclude that in the postmenopausal period the presence of uterine fibroids, endometrial hyperplasia and ovarian tumor formation is accompanied by hyperprolactinemia, hyperandrogenism and hyperestrogenism due to an increase in estrone level. Key words: postmenopausal period, uterine myoma, endometrial hyperplasia, tumor-like formations, hyperandrogenia, hyperprolactinaemia, estrone.