ПОКАЗАТЕЛИ ФУНКЦИОНАЛЬНОЙ АКТИВНОСТИ ТИМУСА, СТВОЛОВЫХ КЛЕТОК И МАРКЕРОВ АПОПТОЗА У БОЛЬНЫХ ЮВЕНИЛЬНЫМ РЕВМАТОИДНЫМ АРТРИТОМ НА САНАТОРНО-КУРОРТНОМ ЭТАПЕ РЕАБИЛИТАЦИИ

Abstract

The aim of the study was to evaluate the effect of sanatorium treatment on the indicators of the functional activity of the thymus, stem cells and apoptosis markers in patients with juvenile rheumatoid arthritis. Material and methods. 48 patients with juvenile rheumatoid arthritis were examined. The effect of sanatorium rehabilitation on the functional activity of the thymus was evaluated by the changes in the release of its main hormone, α1-thymosin, as well as of markers of stem cells (CD34) and apoptosis (CD95). The control group consisted of 15 healthy peers. Results. In juvenile rheumatoid arthritis, the functional activity of the thymus decreases, which is manifested by significantly lower levels of secretion of its main hormone α1-thymosin, which can contribute to the disruption of the processes of T-lymphocyte selection and the appearance of autoreactive clones. There was also a significant increase in stem cell markers (CD34) and markers of the readiness of activated lymphocytes for apoptosis (CD95). This fact indicates the accumulation of poorly differentiated cells in the systemic bloodstream and impaired apoptosis. Sanatorium treatment leads to a significant increase in α1-thymosin and positive changes in CD34 and CD95 levels. Conclusion. The factors contributing to the development of an autoimmune process were identified in patients with juvenile rheumatoid arthritis. A decrease in thymus α1-thymosin, combined with an increased level of CD34 and CD95, can contribute to the impairment of negative selection of T-lymphocytes in the thymus, accumulation of autoreactive clones and poorly differentiated cells that have not undergone apoptosis in the systemic circulation. Sanatorium treatment has a normalizing effect on the parameters under study.